Much of the work in animal models has focused on the indirect downregulation of brain derived neurotrophic factor ( BDNF ) by over-activation of the stress axis.
2.
To overcome the " issue " of having the shear stress axis downward in the Mohr-circle space, there is an " alternative " sign convention where positive shear stresses are assumed to rotate the material element in the clockwise direction and negative shear stresses are assumed to rotate the material element in the counterclockwise direction ( Figure 5, option 3 ).
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